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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1480280생성일: 2026년 10월 26일

2-Amino-3,3-dimethylbutanenitrile → N-(1-cyano-2,2-dimethyl-propyl)-5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxamide

https://huagongshe.com/reaction/1480280

반응식

참여 물질

역할이름HCID투입량
반응물2-Amino-3,3-dimethylbutanenitrileHCID 11378465—
반응물5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acidHCID 90204573—
생성물N-(1-cyano-2,2-dimethyl-propyl)-5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxamideHCID 90214975—

반응 단계

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (Example 68a) and 2-Amino-3,3-dimethyl-butyronitrile (CAN 77425-86-6) as starting materials and isolated (2 g, 99%); MS (ESI, m/z): 370.6 (M+H+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09409866B2
출처 데이터셋uspto-grants-2016_08
ORD IDord-163dd4bb740f4daea0e622d4614505c3
출처 메모uspto-grants-2016_08