Sodium Hydroxide → 2-Methoxy-1,3-thiazole-5-carboxylic acid

HRID 1480388노트

반응식

HRID 1480388 반응식
Cl[C:2]1[S:3][C:4]([C:7]([O:9]C(C)(C)C)=[O:8])=[CH:5][N:6]=1.[CH3:14][O-:15].[Na+].[OH-].[Na+]>CC#N.CO>[CH3:14][O:15][C:2]1[S:3][C:4]([C:7]([OH:9])=[O:8])=[CH:5][N:6]=1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 10942334Sodium MethoxideHCID 24229786tert-Butyl 2-chloro-1,3-thiazole-5-carboxylate

생성물 1

HCID 164948972-Methoxy-1,3-thiazole-5-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 6342Acetonitrile용매

반응 조건

온도
80 °C

실험 절차

To a solution of tert-butyl 2-chlorothiazole-5-carboxylate (100 mg, 0.455 mmol) in MeCN (880 μl) and MeOH (880 ul) was added 5.4M NaOMe in MeOH (337 μl, 1.821 mmol) followed by 2M NaOH (881 μl, 1.762 mmol). The reaction mixture was heated to 80° C. overnight and, after cooling to RT, the mixture was evaporated under reduced pressure. The residue was acidified with a minimal volume of 6M aqueous hydrochloric acid. The resulting precipitate was filtered, washed with water and dried in a high vacuum oven overnight to afford the title compound;

후처리

  1. temperatureafter cooling to RT
  2. customthe mixture was evaporated under reduced pressure
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried in a high vacuum oven overnight

출처 및 근거

ORD 기록
ord-d54a00cbb60c4c57bb0975f2edfc08d4
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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