Sodium Hydroxide → 2-Oxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid

HRID 1480389노트

반응식

HRID 1480389 반응식
C[O:2][C:3]1[S:4][C:5]([C:8]([OH:10])=[O:9])=[CH:6][N:7]=1.C[O-].[Na+].[OH-].[Na+]>CO>[O:2]=[C:3]1[NH:7][CH:6]=[C:5]([C:8]([OH:10])=[O:9])[S:4]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 10942334Sodium MethoxideHCID 164948972-Methoxy-1,3-thiazole-5-carboxylic acid

생성물 1

HCID 200616172-Oxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

2-Methoxythiazole-5-carboxylic acid (step 1) (45.5 mg, 0.286 mmol) was solubilised in MeOH (2 ml) and treated with 5.4M NaOMe in MeOH (212 μl, 1.143 mmol) followed by 2M NaOH (572 μl, 1.143 mmol). The reaction mixture was refluxed overnight and after cooling to RT, the solvent was evaporated under reduced pressure. The residue was acidified with 6M aqueous hydrochloric acid and aqueous layer extracted with EtOAc. The organics were combined and dried over MgSO4 (anh) filtered and evaporated under reduced pressure resulting in a pale yellow solid.

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure
  3. extractionextracted with EtOAc
  4. dry with materialdried over MgSO4 (anh)
  5. filtrationfiltered
  6. customevaporated under reduced pressure
  7. customresulting in a pale yellow solid

출처 및 근거

ORD 기록
ord-03721ea365104971b353daf8f98bb2bd
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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