Sodium Hydroxide → HCID 86722680, 화합물

HRID 1480455노트

반응식

HRID 1480455 반응식
[NH2:1][CH:2]1[CH2:8][CH:7]2[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:4]([CH2:5][CH2:6]2)[CH2:3]1.[C:17](Cl)(=[O:28])[O:18][CH2:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([Cl:27])[CH:21]=1.[OH-].[Na+]>C(Cl)Cl>[Cl:26][C:24]1[CH:25]=[C:20]([CH:21]=[C:22]([Cl:27])[CH:23]=1)[CH2:19][O:18][C:17]([NH:1][CH:2]1[CH2:3][CH:4]2[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:7]([CH2:6][CH2:5]2)[CH2:8]1)=[O:28]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 133055323,5-Dichlorobenzyl ChloroformateHCID 22570519tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

생성물 1

HCID 86722680HCID 86722680, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A reaction mixture comprising of tert-butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate (210 mg, 0.928 mmol), 3,5-dichlorobenzyl carbonochloridate (222 mg, 0.928 mmol), and sodium hydroxide (4.64 ml, 93 mmol) in DCM (3.1 ml) was stirred at room temperature for 4 hours. The reaction mixture separated and the organic portion dried over MgSO4, filtered and concentrated under reduced pressure. No further purification was carried out and the material was taken on crude to the next step.

후처리

  1. customThe reaction mixture separated
  2. dry with materialthe organic portion dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customNo further purification

출처 및 근거

ORD 기록
ord-2a1d1d81d69649968d8a24205b08bc5a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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