Hydrochloric Acid → 3,5-Dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

HRID 1480456노트

반응식

HRID 1480456 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:25]=[C:26]([Cl:28])[CH:27]=1)[CH2:5][O:6][C:7]([NH:9][CH:10]1[CH2:16][CH:15]2[N:17](C(OC(C)(C)C)=O)[CH:12]([CH2:13][CH2:14]2)[CH2:11]1)=[O:8].Cl>O1CCOCC1>[ClH:1].[CH:15]12[NH:17][CH:12]([CH2:13][CH2:14]1)[CH2:11][CH:10]([NH:9][C:7](=[O:8])[O:6][CH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:27]=[C:26]([Cl:28])[CH:25]=1)[CH2:16]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86722680HCID 86722680, 화합물

생성물 1

HCID 867226813,5-Dichlorobenzyl 8-azabicyclo[3.2.1]octan-3-ylcarbamate hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A reaction mixture comprising of tert-butyl 3-((((3,5-dichlorobenzyl)oxy)carbonyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate (388.3 mg, 0.904 mmol) in dioxane (5 mL) was treated with 4M HCl in dioxane (0.678 mL, 2.71 mmol) and stirred at room temperature for 3 hours. The resulting mixture concentrated under reduced pressure. No further purification was carried out and the material was taken on crude to the next step.

후처리

  1. concentrationThe resulting mixture concentrated under reduced pressure
  2. customNo further purification

출처 및 근거

ORD 기록
ord-a7d1343e8cb847c39d82b31d49a4bb99
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

반응 노트

불러오는 중…