Bromine → HCID 86657727, 화합물

HRID 1480656노트

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HRID 1480656 반응식
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

참가 물질

5

반응물 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

생성물 1

HCID 86657727HCID 86657727, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 260Hydrogen Bromide용매

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온도
70 °C

실험 절차

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-eeaecffb40204d3a967c950611a05af3
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409902B2

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