Thiourea → HCID 43141115, 화합물

HRID 1480721노트

반응식

HRID 1480721 반응식
Cl[CH2:2][C:3]([C:5]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[CH:7][C:6]=1[F:13])=O.[NH2:14][C:15]([NH2:17])=[S:16]>CCO>[F:13][C:6]1[CH:7]=[C:8]([F:12])[CH:9]=[C:10]([F:11])[C:5]=1[C:3]1[N:14]=[C:15]([NH2:17])[S:16][CH:2]=1

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 185218922-Chloro-1-(2,4,6-trifluorophenyl)ethan-1-one

생성물 1

HCID 43141115HCID 43141115, 화합물수율 97%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-chloro-1-(2,4,6-trifluorophenyl)ethanone (9.04 g, 43.5 mmol) and thiourea (3.51 g, 46.1 mmol) in 95% EtOH (50 mL) was heated at reflux overnight. The solution was concentrated and mixed with water (100 mL) and saturated aqueous Na2CO3 (5.0 mL). The solids were filtered and dried under vacuum to give 4-(2,4,6-trifluorophenyl)thiazol-2-amine (9.71 g) as pink-white solids in 97% yield: 1H NMR (500 MHz, DMSO-d6) δ 7.26-7.22 (m, 2H), 7.09 (s, 2H), 6.77 (s, 1H).

후처리

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe solution was concentrated
  4. additionmixed with water (100 mL) and saturated aqueous Na2CO3 (5.0 mL)
  5. filtrationThe solids were filtered
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-25cfcda4cb824fcc9bf316e94a71ccf8
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409902B2

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