1-Methylpiperazine → 1-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine

HRID 1480878노트

반응식

HRID 1480878 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

참가 물질

3

반응물 2

HCID 531671-MethylpiperazineHCID 27792505-Fluoro-2-nitroanisole

생성물 1

HCID 567772431-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine

실험 절차

The title compound was prepared according to the method described for Preparations 78 and 79 using 4-fluoro-2-methoxy-1-nitrobenzene and 1-methylpiperazine. The residue was purified by silica gel column chromatography eluting with 0-20% MeOH in EtOAc.

후처리

  1. customThe residue was purified by silica gel column chromatography
  2. washeluting with 0-20% MeOH in EtOAc

출처 및 근거

ORD 기록
ord-c4e51632a78b430a812bec9d65796c9b
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409907B2

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