Methanol → Methyl 2-(chloromethyl)-4-phenoxybenzoate

HRID 1480928노트

반응식

HRID 1480928 반응식
[O:1]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[C:13](=O)[O:12][CH2:11]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B(O)(O)O.C1(P(=O)(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.S(Cl)([Cl:44])=O.[CH3:46][OH:47]>>[CH3:46][O:47][C:13](=[O:12])[C:14]1[CH:15]=[CH:16][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:9][C:10]=1[CH2:11][Cl:44]

참가 물질

6

반응물 5

HCID 887MethanolHCID 7628Boric AcidHCID 13097Triphenylphosphine OxideHCID 24386Thionyl ChlorideHCID 445585805-Phenoxy-2-benzofuran-1(3H)-one

생성물 1

HCID 86709143Methyl 2-(chloromethyl)-4-phenoxybenzoate

실험 절차

To a solid mixture of 5-phenoxy-3H-isobenzofuran-1-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHCO3 solution. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. 1H NMR in CDCl3, δ in ppm: 7.91 (d, 1H, 8.6 Hz), 7.5-6.9 (m, 7H), 5.06 (s, 2H), 3.83 (s, 3H).

후처리

  1. temperatureThe resulting mixture was refluxed overnight
  2. temperatureAfter cooled
  3. temperatureIt was then refluxed for 1 h
  4. concentrationconcentrated
  5. customResidue was partitioned between EtOAc and saturated NaHCO3 solution
  6. washThe organic layer was washed with brine
  7. dry with materialdried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated

출처 및 근거

ORD 기록
ord-141f421edc7e4630b4a890b37cbc97cb
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409892B2

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