Tert-butyl 2-cyano-2,2-dimethylacetate → Tert-butyl 3-amino-2,2-dimethylpropanoate
반응식
[C:1]([O:5][C:6](=[O:12])[C:7]([C:10]#[N:11])([CH3:9])[CH3:8])([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[C:1]([O:5][C:6](=[O:12])[C:7]([CH3:9])([CH3:8])[CH2:10][NH2:11])([CH3:4])([CH3:2])[CH3:3]참가 물질
4
실험 절차
A mixture of cyano-dimethyl-acetic acid tert-butyl ester (5.3 g) and Raney Ni (2 mL in water) in MeOH (400 mL) was stirred at rt under H2 atmosphere (balloon) overnight. Then the reaction mixture was filtered over Celite pad, filtrate was concentrated to give the desired product (5 g). 1H NMR in CDCl3, δ in ppm: 2.8 (br, 2H), 1.45 (s, 9H), 1.17 (s, 6H).
후처리
- filtrationThen the reaction mixture was filtered over Celite pad, filtrate
- concentrationwas concentrated
출처 및 근거
- ORD 기록
- ord-7419d1b1112e4b1f9e5e5ffa7d83e30d
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09409892B2
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