HCID 58820945, 화합물 → HCID 81947339, 화합물
반응식
[C:1]([O:5][C:6](=[O:13])[C:7]([C:11]#[N:12])([CH3:10])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2]>CCO.[Ni]>[C:1]([O:5][C:6](=[O:13])[C:7]([CH2:11][NH2:12])([CH3:10])[CH2:8][CH3:9])([CH3:2])([CH3:3])[CH3:4]참가 물질
4
실험 절차
To a slurry of Raney-Ni (2.9 g, 50% in H2O, rinsed 3 times with EtOH before use) in EtOH (40 mL) was added 2-cyano-2-methyl-butyric acid tert-butyl ester (650 mg, 3.55 mmol). The resulting mixture was stirred under a hydrogen atmosphere at room temperature for 16 hours. The liquid was then carefully decanted into another flask and the metal was washed twice with EtOH. The combined EtOH solution was concentrated in vacuo to give the title compound in 600 mg, which was used directly in the subsequent step without further purification.
후처리
- customThe liquid was then carefully decanted into another flask
- washthe metal was washed twice with EtOH
- concentrationThe combined EtOH solution was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-d75e0caab90b4048af11b133e860af83
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09409892B2
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