HCID 89812992, 화합물 → HCID 89813147, 화합물
반응식
[C:1]([O:5][C:6](=[O:17])[CH:7]([C:15]#[N:16])[C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>[Ni].CO>[C:1]([O:5][C:6](=[O:17])[CH:7]([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)[CH2:15][NH2:16])([CH3:4])([CH3:2])[CH3:3]참가 물질
4
실험 절차
Cyano-(4-fluoro-phenyl)-acetic acid tert-butyl ester (3.78 g) was mixed with Raney nickel (5 mL, 50% water) in MeOH (100 mL) and stirred under hydrogen balloon at rt overnight. The mixture was then filtered through Celite, concentrated to give crude, which was silica gel column purified to give 3-amino-2-(4-fluoro-phenyl)-propionic acid tert-butyl ester (1.3 g).
후처리
- filtrationThe mixture was then filtered through Celite
- concentrationconcentrated
- customto give crude, which
- custompurified
출처 및 근거
- ORD 기록
- ord-0fce86e6bf4443e3aaa3408f06c5f8a7
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09409892B2
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