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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → 6-(2-amino-2,3-dihydro-1H-pyrrolo[1,2-a]indol-7-yl)-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride

HRID 1481794
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HRID 1481794 반응식
[NH2:1][CH:2]1[CH2:46][N:5]2[C:6]3[CH:7]=[CH:8][C:9]([C:13]4[C:28]([CH3:29])=[C:27]([O:30]CC5C=CC=CC=5)[C:16]([C:17]([O:19]CC5C=CC=CC=5)=[O:18])=[C:15]([O:38]CC5C=CC=CC=5)[N:14]=4)=[CH:10][C:11]=3[CH:12]=[C:4]2[CH2:3]1.[ClH:47]>CO.[Pd]>[ClH:47].[NH2:1][CH:2]1[CH2:46][N:5]2[C:6]3[CH:7]=[CH:8][C:9]([C:13]4[NH:14][C:15](=[O:38])[C:16]([C:17]([OH:19])=[O:18])=[C:27]([OH:30])[C:28]=4[CH3:29])=[CH:10][C:11]=3[CH:12]=[C:4]2[CH2:3]1
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참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 71284437benzyl 6-(2-amino-2,3-dihydro-1H-pyrrolo[1,2-a]indol-7-yl)-2,4-bis(benzyloxy)-5-methylnicotinate

생성물 1

HCID 712849696-(2-amino-2,3-dihydro-1H-pyrrolo[1,2-a]indol-7-yl)-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid hydrochloride수율 49%

시약·촉매·용매 2

HCID 23938Palladium촉매
HCID 887
Methanol
용매
2회

실험 절차

The intermediate from Step 4 (36 mg, 0.06 mmol) was dissolved in MeOH (2 mL). To the solution was added 10% Pd/C (20 mg) and 3 N HCl in MeOH (0.1 mL). The mixture stirred under H2 (1 atm) at room temperature for 16 h. The mixture was filtered through a 5 μm cartridge. The filtrate was concentrated, leaving the product (21 mg, 49%) as an off white powder.

후처리

  1. filtrationThe mixture was filtered through a 5 μm cartridge
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-0d21195e1604436a8032c56df8a5fe8b
출처 데이터셋
uspto-grants-2016_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09409905B2

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