홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylethylamine → HCID 86716013, 화합물

HRID 1482500
노트
인쇄 미리보기

반응식

HRID 1482500 반응식
[N:1]1([CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH2:8][NH2:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:18]=1[C:19](O)=[O:20].C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>C(Cl)Cl>[Cl:16][C:17]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:18]=1[C:19]([NH:9][CH2:8][CH:7]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)=[O:20]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 2404302-Chloro-5-methylbenzoic AcidHCID 2724699PyBOPHCID 167675312-(Morpholin-4-yl)-2-(pyridin-2-yl)ethan-1-amine

생성물 1

HCID 86716013HCID 86716013, 화합물수율 92.6%

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

A mixture of (2-morpholin-4-yl-2-pyridin-2-ylethyl)amine (62.2 mg, 0.3 mmol), 2-chloro-5-methylbenzoic acid (54 mg, 0.315 mmol), PyBOP (187 mg, 0.36 mmol) and DIPEA (78 mg, 0.60 mmol) in DCM (1.5 mL) was stirred at room temperature overnight. The mixture was purified by preparative HPLC to yield the title compound (100 mg, yield: 90%). LCMS (MH+): m/z=360.0, tR (minutes, Method A)=0.89

후처리

  1. customThe mixture was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-9fec2a3cd58840548d0067ee2ca0fa30
출처 데이터셋
uspto-grants-2016_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09415055B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트