Sodium Hydroxide → (Pyrimidin-4-yl)acetic acid

HRID 1483981노트

반응식

HRID 1483981 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10]CC)=[O:9])=[N:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[N:3][CH:2]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20295406Ethyl 2-(pyrimidin-4-yl)acetate

생성물 1

HCID 21486925(Pyrimidin-4-yl)acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 2-(pyrimidin-4-yl)acetate (Example 33b, 450 mg, 2.71 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 24 hours, concentrated under reduced pressure and suspended in ethanol. The solid was removed by vacuum filtration, and the filtrate was concentrated under reduced pressure, triturated with ethanol, concentrated again and carried onto the next step without further purification. MS 139 (MH+).

후처리

  1. concentrationconcentrated under reduced pressure
  2. customThe solid was removed by vacuum filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customtriturated with ethanol
  5. concentrationconcentrated again
  6. customcarried onto the next step without further purification

출처 및 근거

ORD 기록
ord-361ede2119cf4039907e1de3ac2f6a9d
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09420814B2

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