Tetraethyl 5,5'-(1,8-naphthyridine-2,7-diyl)diisophthalate → 5,5'-(1,8-Naphthyridine-2,7-diyl)diisophthalic acid

HRID 1484218노트

반응식

HRID 1484218 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([C:22]([O:24]CC)=[O:23])[CH:14]=[C:15]([CH:21]=3)[C:16]([O:18]CC)=[O:17])[N:9]=2)[CH:4]=[CH:3][C:2]=1[C:27]1[CH:28]=[C:29]([C:38]([O:40]CC)=[O:39])[CH:30]=[C:31]([CH:37]=1)[C:32]([O:34]CC)=[O:33]>C1COCC1.CO.[OH-].[Na+]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]3[CH:21]=[C:15]([C:16]([OH:18])=[O:17])[CH:14]=[C:13]([CH:12]=3)[C:22]([OH:24])=[O:23])[N:9]=2)[CH:4]=[CH:3][C:2]=1[C:27]1[CH:37]=[C:31]([C:32]([OH:34])=[O:33])[CH:30]=[C:29]([CH:28]=1)[C:38]([OH:40])=[O:39]

참가 물질

5

반응물 1

HCID 117940372Tetraethyl 5,5'-(1,8-naphthyridine-2,7-diyl)diisophthalate

생성물 1

HCID 706984375,5'-(1,8-Naphthyridine-2,7-diyl)diisophthalic acid

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 14798Sodium Hydroxide용매

실험 절차

2.0 g of tetraethyl 5,5′-(1,8-naphthyridine-2,7-diyl)diisophthalate was dissolved in 60 mL of mixed solvent of THF and MeOH (v/v=1:1), 20 mL of 2N NaOH aqueous solution was added. The mixture was stirred at room temperature overnight. After the organic phase was removed, the aqueous phase was acidified with dilute hydrochloric acid to give white precipitate, which was filtered and washed with water several times. Yield: 1.5 g, 94%. 1H NMR (300 MHz, DMSO-d6): δ 8.44 (d, 2H), 8.62 (s, 2H), 8.68 (d, 2H), 9.10 (s, 4H).

후처리

  1. additionwas added
  2. customAfter the organic phase was removed
  3. customto give white precipitate, which
  4. filtrationwas filtered
  5. washwashed with water several times

출처 및 근거

ORD 기록
ord-9af959f2d5604b48a87bb48424671ff9
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09421514B2

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