Hydrogen Bromide → 2-(Bromomethyl)-5-(difluoromethoxy)-1,3-difluorobenzene

HRID 1484684

반응식

HRID 1484684 반응식
[F:1][CH:2]([F:14])[O:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([CH2:11]O)=[C:6]([F:13])[CH:5]=1.[BrH:15]>C(OCC)C>[Br:15][CH2:11][C:7]1[C:8]([F:10])=[CH:9][C:4]([O:3][CH:2]([F:14])[F:1])=[CH:5][C:6]=1[F:13]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 69140944Benzenemethanol, 4-(difluoromethoxy)-2,6-difluoro-

생성물 1

HCID 867324312-(Bromomethyl)-5-(difluoromethoxy)-1,3-difluorobenzene수율 67%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

162 mg [4-(difluoromethoxy)-2,6-difluorophenyl]methanol (0.769 mmol, 1.0 eq.) were dissolved in 0.348 mL hydrogen bromide (2.12 mmol, 2.8 eq.). and stirred at rt over night. The reaction mixture was diluted with diethylether and stirred for 5 minutes. The aqueous layer was washed twice with diethylether. The combined organic layers were washed with brine, dried over a silicon filter and concentrated in vacuo to provide the 149 mg (0.51 mmol, 67%) of the crude product, which was used without further purification.

후처리

  1. stirringstirred for 5 minutes
  2. washThe aqueous layer was washed twice with diethylether
  3. washThe combined organic layers were washed with brine
  4. customdried over a silicon
  5. filtrationfilter
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f4794655fd6a4886a308cec0c6a0f560
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422268B2

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