Water → HCID 84016145, 화합물

HRID 1485028노트

반응식

HRID 1485028 반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:18])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])C.[Li+].[OH-].O>C1COCC1.CO>[CH3:18][N:9]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]1

참가 물질

5

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 867185501-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester

생성물 1

HCID 84016145HCID 84016145, 화합물

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.55 g; 91.37 mmol) was dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 182.73 mmol) was added. After 16 hours at ambient temperature the reaction mixture was washed with EtOAc. The aqueous layer was acidified with 1 N HCl and extracted with EtOAc which was dried and evaporated afterwards.

후처리

  1. washAfter 16 hours at ambient temperature the reaction mixture was washed with EtOAc
  2. extractionextracted with EtOAc which
  3. customwas dried
  4. customevaporated afterwards

출처 및 근거

ORD 기록
ord-3d7606fdbb88412eade1017ed4fd0554
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422290B2

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