4-Hydroxybenzaldehyde → 4-(Cyclopropylmethoxy)benzaldehyde

HRID 1485056노트

반응식

HRID 1485056 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH:18]1[CH2:20][CH2:19]1>CC(C)=O>[CH:18]1([CH2:17][O:1][C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)[CH2:20][CH2:19]1

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 81503Bromomethylcyclopropane

생성물 1

HCID 5432414-(Cyclopropylmethoxy)benzaldehyde수율 91.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a mixture of 4-hydroxybenzaldehyde (2.00 g), potassium carbonate (4.53 g) and acetone (50.0 mL), (bromomethyl)cyclopropane (3.32 g) was added and the mixture was refluxed for 9 hours. After cooling the reaction mixture to room temperature, the resulting precipitate was removed by filtration through Celite (registered trademark). The filtrate was concentrated under reduced pressure and, thereafter, the resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=90:10-50:50) to give the titled compound as a colorless oil (2.63 g).

후처리

  1. additionwas added
  2. temperaturethe mixture was refluxed for 9 hours
  3. customthe resulting precipitate was removed by filtration through Celite (registered trademark)
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customthe resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=90:10-50:50)

출처 및 근거

ORD 기록
ord-7126be6f684c46649b6767ebd4077f8c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422240B2

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