Hydrochloric Acid → HCID 88415079, 화합물

HRID 1486261노트

반응식

HRID 1486261 반응식
[NH2:1][C:2]([CH3:16])([C:12]([F:15])([F:14])[F:13])[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[ClH:17].[F:13][C:12]([F:15])([F:14])[C:2]([CH3:16])([NH2:1])[CH2:3][NH2:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 90136051rac-tert-Butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate

생성물 1

HCID 88415079HCID 88415079, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

15 g (61.9 mmol) of rac-tert-butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate from Example 51A in dioxane (188 ml) were admixed with 188 ml of 4 M hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 16 h, then concentrated and stored under argon. This gave 14.4 g (108% of theory) of the target compound, which was not purified any further.

후처리

  1. concentrationconcentrated
  2. customThis gave 14.4 g (108% of theory) of the target compound, which was not purified any further

출처 및 근거

ORD 기록
ord-97e5fa5daa2b487693a6cc4234586815
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422285B2

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