Hydrogen Peroxide → 4-Chloro-3,5-bis(trifluoromethyl)benzamide

HRID 1487007노트

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HRID 1487007 반응식
[Cl:1][C:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].C([O-])([O-])=[O:19].[K+].[K+].OO>CS(C)=O>[Cl:1][C:2]1[C:3]([C:14]([F:15])([F:16])[F:17])=[CH:4][C:5]([C:6]([NH2:7])=[O:19])=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13]

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 226251933,5-Bis(trifluoromethyl)-4-chlorobenzonitrile

생성물 1

HCID 867303704-Chloro-3,5-bis(trifluoromethyl)benzamide수율 93.8%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

4-Chloro-3,5-bis(trifluoromethyl)benzonitrile (1 g, 1.0 eq.) was dissolved in DMSO (10 mL). K2CO3 (0.55 g, 1.1 eq.) and H2O2 (1 mL) were added to the reaction mixture and stirred at room temperature for 2-3 h, then poured into ice water (20 mL). The precipitate formed was collected by filtration and washed with petroleum ether to afford 1.0 g of crude product (90% yield), which was used without further purification in the next step.

후처리

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with petroleum ether

출처 및 근거

ORD 기록
ord-00da5095a4d148659b177c1fa89bca13
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428490B2

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