Sodium Hydroxide → 1,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

HRID 1487272노트

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HRID 1487272 반응식
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[C:8](=[O:12])[N:7]([CH3:13])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[CH3:13][N:7]1[C:8](=[O:12])[C:9]([CH3:11])=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 117889483Methyl 1,5-dimethyl-6-oxopyridine-3-carboxylate

생성물 1

HCID 218859251,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
100 °C

실험 절차

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester C-1 (2.60 g; 14.35 mmol) is suspended in MeOH. Sodium hydroxide (1 M solution, 45 ml; 45.00 mmol) is added and the reaction mixture is heated up to 100° C. (Drysyn, reflux) for 2 h. MeOH is removed under reduced pressure and 1N HCl (46 ml) is added to the solution, precipitation occurs. The precipitate is filtered off and dried under reduced pressure.

후처리

  1. temperature(Drysyn, reflux) for 2 h
  2. customMeOH is removed under reduced pressure and 1N HCl (46 ml)
  3. additionis added to the solution, precipitation
  4. filtrationThe precipitate is filtered off
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-0c64059cd1764151813a7a7f79d8bb53
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428515B2

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