Trifluoroacetic acid → 2-cyano-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(methylsulfonamidomethyl)pyridin-3-yl)phenyl)propan-2-yl)acetamide

반응식

[F:1][CH2:2][C@@H:3]1[C@@H:7]([C:8]2[CH:13]=[CH:12][C:11]([Sn](C)(C)C)=[CH:10][CH:9]=2)[O:6]C(C)(C)[N:4]1[C:20](=[O:24])[CH2:21][C:22]#[N:23].Br[C:26]1[CH:27]=[CH:28][C:29]([CH2:32][NH:33][S:34]([CH3:37])(=[O:36])=[O:35])=[N:30][CH:31]=1.O1C=CC=C1P(C1OC=CC=1)C1OC=CC=1.FC(F)(F)C(O)=O>CN(C)C=O.O.C(Cl)Cl.C1(C)C=CC=CC=1.[Pd].[Pd].C(=CC(C=CC1C=CC=CC=1)=O)C1C=CC=CC=1.C(=CC(C=CC1C=CC=CC=1)=O)C1C=CC=CC=1.C(=CC(C=CC1C=CC=CC=1)=O)C1C=CC=CC=1>[C:22]([CH2:21][C:20]([NH:4][C@H:3]([CH2:2][F:1])[C@H:7]([OH:6])[C:8]1[CH:9]=[CH:10][C:11]([C:26]2[CH:31]=[N:30][C:29]([CH2:32][NH:33][S:34]([CH3:37])(=[O:35])=[O:36])=[CH:28][CH:27]=2)=[CH:12][CH:13]=1)=[O:24])#[N:23]