Bromocyclopentane → Cyclopentyltriphenylphosphonium bromide

HRID 1487811

반응식

HRID 1487811 반응식
[Br:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH2:3]1.[C:7]1([P:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1(C)C=CC=CC=1>[Br-:1].[CH:2]1([P+:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 8728BromocyclopentaneHCID 11776Triphenylphosphine

생성물 1

HCID 2735896Cyclopentyltriphenylphosphonium bromide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Bromocyclopentane and triphenylphosphine are directly heated to 110° C. for 6 hrs in the absence of a solvent, and part of the unreacted raw material is dissolved in toluene, to obtain cyclopentyl triphenylphosphonium bromide. The resulting cyclopentyl triphenylphosphonium bromide is reacted with potassium tert-butoxide in the solvent tetrahydrofuran at 0° C. to generate the corresponding Ylide reagent, which undergoes Witting reaction with

출처 및 근거

ORD 기록
ord-b7451582eec04e62aa322dc410f98d95
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428693B2

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