Hydrochloric Acid → 4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)

HRID 1487814노트

반응식

HRID 1487814 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:12]1[CH2:13][CH2:14][CH:9]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:10][CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate2회

생성물 1

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)수율 57%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Into a 500-mL three neck round-bottom flask, was placed a solution of tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (compound 1.1, 20 g, crude) in ethyl acetate (200 mL). Hydrogen chloride (gas) was introduced to the solution and the resulting mixture was stirred for 30 min at room temperature. The solids were collected by filtration, then washed with ethyl acetate (100 mL) and ether (100 mL) to yield the title compound as a white solid (14 g, 57% over two steps).

후처리

  1. filtrationThe solids were collected by filtration
  2. washwashed with ethyl acetate (100 mL) and ether (100 mL)

출처 및 근거

ORD 기록
ord-a799ca846b054023849e06efd76ff7ed
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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