Sodium Hydroxide → 3-(5-Chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoic acid

HRID 1487847노트

반응식

HRID 1487847 반응식
[Cl:1][C:2]1[NH:6][C:5]([CH3:7])=[N:4][C:3]=1[C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[CH3:18])[C:11]([O:13]C)=[O:12].[OH-].[Na+]>CO>[Cl:1][C:2]1[NH:6][C:5]([CH3:7])=[N:4][C:3]=1[C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[CH3:18])[C:11]([OH:13])=[O:12]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 90030158Methyl 3-(5-chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoate2회

생성물 1

HCID 900302003-(5-Chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

A mixture of methyl 3-(5-chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoate (compound 7.2, 10 mg, 0.038 mmol) in methanol (2 mL) and aqueous NaOH (2M, 0.2 mL, 0.4 mmol) was stirred at 50° C. for 16 hrs. The organic solvent was removed under reduced pressure and aqueous HCl (2 M) was added to the residue until a pH˜3-4 was attained. The solvents were removed under reduced pressure to produce a white solid which was a mixture of the title compound and salts and used in the next step without further purification. m/z (ES−) 249 (M−H)−.

후처리

  1. customThe organic solvent was removed under reduced pressure and aqueous HCl (2 M)
  2. additionwas added to the residue until a pH˜3-4
  3. customThe solvents were removed under reduced pressure
  4. customto produce a white solid which

출처 및 근거

ORD 기록
ord-38bf2efa817d4226a254572e806cbe14
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

반응 노트

불러오는 중…