Sodium Hydroxide → 3-Bromo-4-cyclopropylbenzoic acid

HRID 1487855노트

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HRID 1487855 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH:12]1[CH2:14][CH2:13]1)[C:5]([O:7]C)=[O:6].[OH-].[Na+]>CO.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH:12]1[CH2:13][CH2:14]1)[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 44828964Methyl 3-bromo-4-cyclopropylbenzoate2회

생성물 1

HCID 448285263-Bromo-4-cyclopropylbenzoic acid수율 63.5%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

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온도
50 °C

실험 절차

Into a 50-mL round-bottom flask, was placed a solution of methyl 3-bromo-4-cyclopropylbenzoate (compound 10.2, 500 mg, 1.96 mmol) in methanol (10 mL) and a solution of sodium hydroxide (500 mg, 12.5 mmol) in water (5 mL). The resulting solution was stirred overnight at 50° C., then the volatiles were removed under reduced pressure. The pH of the residual solution was adjusted to 6-7 with aqueous HCl (6 M). The resulting solids were collected by filtration to yield 0.3 g (63%) of the title compound as a white solid.

후처리

  1. customInto a 50-mL round-bottom flask, was placed
  2. customthe volatiles were removed under reduced pressure
  3. filtrationThe resulting solids were collected by filtration

출처 및 근거

ORD 기록
ord-5cfa2065b1fe406cae35342886381f3c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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