N-Iodosuccinimide → 5-Iodo-2-methyl-1H-imidazole-4-carbonitrile

HRID 1487865노트

반응식

HRID 1487865 반응식
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[N:8])[N:6]=1.[I:9]N1C(=O)CCC1=O>C(#N)C>[I:9][C:4]1[NH:3][C:2]([CH3:1])=[N:6][C:5]=1[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 178432957HCID 178432957, 화합물2회

생성물 1

HCID 900304155-Iodo-2-methyl-1H-imidazole-4-carbonitrile수율 55%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Into a 25-mL round-bottom flask, was placed a mixture of 2-methyl-1H-imidazole-4-carbonitrile (compound 16.3, 50 mg, 0.47 mmol), N-iodosuccinimide (116 mg, 0.52 mmol) in ACN (5 mL). The resulting solution was heated at reflux overnight, then cooled to room temperature and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1/2) to yield 60 mg (55%) of the title compound as a light yellow solid.

후처리

  1. customInto a 25-mL round-bottom flask, was placed
  2. temperatureThe resulting solution was heated
  3. temperatureat reflux overnight
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1/2)

출처 및 근거

ORD 기록
ord-c2e7f8662d6145b2861a6a00ddf5e93d
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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