Sodium Hydroxide → HCID 178432710, 화합물

HRID 1487910노트

반응식

HRID 1487910 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[C:12]1[NH:16][C:15]([CH3:17])=[N:14][C:13]=1[CH3:18].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[C:12]1[NH:16][C:15]([CH3:17])=[N:14][C:13]=1[CH3:18]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 178497889HCID 178497889, 화합물2회

생성물 1

HCID 178432710HCID 178432710, 화합물수율 94%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 4-chloro-3-(2,4-dimethyl-1H-imidazol-5-yl)benzoate (compound 50.3, 270 mg, 1.02 mmol) was dissolved in methanol (20 mL) and aqueous NaOH (2 M, 6 mL) then heated to 50° C. for 16 hrs. The volatile solvents were removed under reduced pressure and the resulting aqueous phase was acidified to pH 5-6 with aqueous HCl (2M). The precipitated solids were filtered, and dried to yield 230 mg (94%) of the title compound as a white solid. m/z (ES−) 249 (M−H)−

후처리

  1. customThe volatile solvents were removed under reduced pressure
  2. filtrationThe precipitated solids were filtered
  3. customdried

출처 및 근거

ORD 기록
ord-c90b883a02674639bdf7ba0dc4307f29
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

반응 노트

불러오는 중…