Methyl 3-(4-chloro-1H-pyrazol-5-yl)-4-methylbenzoate → 3-(4-Chloro-1H-pyrazol-3-yl)-4-methylbenzoic acid

HRID 1487913노트

반응식

HRID 1487913 반응식
[Cl:1][C:2]1[CH:3]=[N:4][NH:5][C:6]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:10]([O:12]C)=[O:11]>[OH-].[Na+].CO>[Cl:1][C:2]1[CH:3]=[N:4][NH:5][C:6]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][C:16]=1[CH3:17])[C:10]([OH:12])=[O:11]

참가 물질

4

반응물 1

HCID 90030357Methyl 3-(4-chloro-1H-pyrazol-5-yl)-4-methylbenzoate2회

생성물 1

HCID 900296813-(4-Chloro-1H-pyrazol-3-yl)-4-methylbenzoic acid수율 119.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
50 °C

실험 절차

Methyl 3-(4-chloro-1H-pyrazol-5-yl)-4-methylbenzoate (compound 51.2, 133 mg, 0.53 mmol) was dissolved in a mixture of aqueous NaOH (2 M, 3 mL) and methanol (10 mL). The solution was heated at 50° C. for 16 hrs then the volatiles were removed under reduced pressure. Aqueous HCl (2 M) was added to adjust the pH to 4-5 then concentrated to yield 150 mg of a white solid which was used in the next step without further purification. m/z (ES−) 235 (M−H)−.

후처리

  1. customthe volatiles were removed under reduced pressure
  2. additionAqueous HCl (2 M) was added
  3. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-2464da9b9d7a4cc89c2a8861a9d1a5f0
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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