Hydrochloric Acid → Methyl 4-cyclobutyl-5-(1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepin-2-yl)-2-methylbenzoate hydrochloride

HRID 1487955노트

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HRID 1487955 반응식
[CH:1]1([C:5]2[CH:10]=[C:9]([CH3:11])[C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C:6]=2[C:16]2[NH:32][C:19]3[CH2:20][CH2:21][N:22](C(OC(C)(C)C)=O)[CH2:23][CH2:24][C:18]=3[N:17]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:33]>CCOC(C)=O>[ClH:33].[CH:1]1([C:5]2[C:6]([C:16]3[NH:17][C:18]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20][C:19]=4[N:32]=3)=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[C:9]([CH3:11])[CH:10]=2)[CH2:2][CH2:3][CH2:4]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 90066675t-Butyl 2-(2-cyclobutyl-5-(methoxycarbonyl)-4-methylphenyl)-4,5,7,8-tetrahydroimidazo[4,5-d]azepine-6(1H)-carboxylate2회

생성물 1

HCID 118250742Methyl 4-cyclobutyl-5-(1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepin-2-yl)-2-methylbenzoate hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Into a 50-mL 3-necked round-bottom flask, was placed a solution of tert-butyl 2-(2-cyclobutyl-5-(methoxycarbonyl)-4-methylphenyl)-4,5,7,8-tetrahydroimidazo[4,5-d]azepine-6(1H)-carboxylate (compound 82.6, 200 mg, 0.46 mmol) in EtOAc (10 mL). Hydrogen chloride (gas) was introduced into the solution by bubbling and the solution was stirred for 30 min at room temperature. The resulting mixture was concentrated under reduced pressure to yield 136 mg (crude) of the title compound as a yellow solid.

후처리

  1. customInto a 50-mL 3-necked round-bottom flask, was placed
  2. customby bubbling
  3. concentrationThe resulting mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3c7bbd3c93b246c4a07eb05d747f30a1
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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