HCID 178494667, 화합물 → HCID 178424688, 화합물

반응식

C[O:2][CH2:3][C:4]1[NH:5][C:6]([C:10]2[C:11]([CH3:21])=[CH:12][C:13]([CH3:20])=[C:14]([CH:19]=2)[C:15]([O:17]C)=[O:16])=[C:7]([CH3:9])[N:8]=1>Br>[OH:2][CH2:3][C:4]1[NH:5][C:6]([C:10]2[C:11]([CH3:21])=[CH:12][C:13]([CH3:20])=[C:14]([CH:19]=2)[C:15]([OH:17])=[O:16])=[C:7]([CH3:9])[N:8]=1

참가 물질

반응 조건

온도: 80 °C

실험 절차

Into a 100-mL round-bottom flask, was placed methyl 5-(2-(methoxymethyl)-4-methyl-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 222.4, 220 mg, 0.76 mmol) and HBr (20 mL, 40% in HOAc). The reaction mixture was stirred overnight at 80° C. The resulting mixture was concentrated under reduced pressure. This resulted in 190 ma (crude) of the title compound as a brown solid.

후처리

customInto a 100-mL round-bottom flask, was placed
concentrationThe resulting mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-11a9c9d7ef35491db59acab365b86621
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09428502B2

반응 노트

불러오는 중…

참가 물질

반응물 1

HCID 178494667HCID 178494667, 화합물2회

생성물 1

HCID 178424688HCID 178424688, 화합물

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매

반응 조건

온도: 80 °C

실험 절차

후처리

customInto a 100-mL round-bottom flask, was placed
concentrationThe resulting mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-11a9c9d7ef35491db59acab365b86621
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09428502B2

반응 노트

불러오는 중…