Sodium Hydroxide → 3-(4-Methoxy-1H-pyrazol-5-yl)-4-methylbenzoic acid

HRID 1488141노트

반응식

HRID 1488141 반응식
[CH3:1][O:2][C:3]1[CH:4]=[N:5][NH:6][C:7]=1[C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[CH3:18])[C:11]([O:13]C)=[O:12].[OH-].[Na+]>CO.O>[CH3:1][O:2][C:3]1[CH:4]=[N:5][NH:6][C:7]=1[C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[CH3:18])[C:11]([OH:13])=[O:12]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 90030202Methyl 3-(4-methoxy-1H-pyrazol-5-yl)-4-methylbenzoate2회

생성물 1

HCID 900296623-(4-Methoxy-1H-pyrazol-5-yl)-4-methylbenzoic acid수율 208.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

Into a 50-mL round-bottom flask, was placed a solution of methyl 3-(4-methoxy-1H-pyrazol-5-yl)-4-methylbenzoate (compound 244.6, 180 mg, 0.73 mmol) in methanol (4 mL). Sodium hydroxide (117 mg, 2.92 mmol) in water (2 mL) was added and the resulting solution was stirred for 3 h at 60° C., then concentrated under reduced pressure. The pH of the residue was adjusted to 1 with aqueous hydrogen chloride (1 M), then concentrated under reduced pressure. Methanol (5 mL) was added to the residue and the solids were filtered from the solution. The filtrate was concentrated under reduced pressure to obtain the title compound as a limit yellow solid (353 mg, crude).

후처리

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationconcentrated under reduced pressure
  3. concentrationconcentrated under reduced pressure
  4. additionMethanol (5 mL) was added to the residue
  5. filtrationthe solids were filtered from the solution
  6. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e565b459ca494b4caaae3d29ce9d7bc7
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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