Sodium Methoxide → HCID 90021327, 화합물

HRID 1488173노트

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HRID 1488173 반응식
[O:1]1[CH2:5][CH2:4][CH:3]([C:6](=[O:9])[CH2:7][CH3:8])[CH2:2]1.[CH3:10][O-:11].[Na+]>C(OCC)=O>[CH3:8][CH:7]([C:6](=[O:9])[CH:3]1[CH2:4][CH2:5][O:1][CH2:2]1)[CH:10]=[O:11]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 21702750HCID 21702750, 화합물2회

생성물 1

HCID 90021327HCID 90021327, 화합물수율 66%

시약·촉매·용매 1

HCID 8025Ethyl formate용매

실험 절차

Into a 100-mL round-bottom flask, was placed 1-(tetrahydrofuran-3-yl)propan-1-one (compound 263.2, 2.5 g, 19.5 mmol), sodium methoxide (1.4 g, 25.9 mmol) and ethyl formate (20 mL). The mixture was stirred overnight at room temperature, then concentrated under reduced pressure. The residue was purified by a silica gel column chromatography with ethyl acetate/petroleum ether (1:20 to 1:5) as eluent to obtain the title compound as a yellow solid (2.0 g, 66%).

후처리

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by a silica gel column chromatography with ethyl acetate/petroleum ether (1:20 to 1:5) as eluent

출처 및 근거

ORD 기록
ord-3ab0b34df5c24500a7d02cc7d3e1aad8
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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