1,2-Dichloroethane → benzyl 6-{bis[2-({2-[(alpha-L-fucopyranosyl)oxy]ethyl}amino)-2-oxoethyl]amino}-6-oxohexanoate
반응식
[CH2:1]([O:8][C:9](=[O:25])[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([N:16]([CH2:21][C:22]([OH:24])=O)[CH2:17][C:18]([OH:20])=O)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:26]([CH2:37][CH2:38][NH2:39])[C@@H:27]1[O:35][C@@H:34]([CH3:36])[C@@H:32]([OH:33])[C@@H:30]([OH:31])[C@@H:28]1[OH:29].[CH2:40](Cl)[CH2:41]Cl>CN(C=O)C.CN(C1C=CN=CC=1)C>[C@@H:27]1([O:26][CH2:37][CH2:38][NH:39][C:22](=[O:24])[CH2:21][N:16]([CH2:17][C:18](=[O:20])[NH:39][CH2:38][CH2:37][O:26][C@@H:27]2[O:35][C@@H:40]([CH3:41])[C@@H:32]([OH:33])[C@@H:30]([OH:31])[C@@H:28]2[OH:29])[C:14](=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10][C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[O:25])[O:35][C@@H:34]([CH3:36])[C@@H:32]([OH:33])[C@@H:30]([OH:31])[C@@H:28]1[OH:29]참가 물질
6
반응물 3
생성물 1
시약·촉매·용매 2
실험 절차
To a stirred solution of 2,2′-{[6-(benzyloxy)-6-oxohexanoyl]imino}diacetic acid (800 mg, 2.277 mmol) in DMF (12 mL) at room temperature was added 2-aminoethyl α-L-fucopyranoside (1.132 g, 5.46 mmol), DMAP (834 mg, 6.83 mmol) and EDC (1.528 g, 7.97 mmol). After stirring at rt for 16 hr, the reaction mixture was concentrated and the residue was purified by flash chromatography on C18 reverse phase silica gel (120 g), eluting with 0-40% AcCN in water, to give the title compound. LC-MS Method A: m/e=730.26 [M+1]; Rt=1.42 min.
후처리
- concentrationthe reaction mixture was concentrated
- customthe residue was purified by flash chromatography on C18 reverse phase silica gel (120 g)
- washeluting with 0-40% AcCN in water
출처 및 근거
- ORD 기록
- ord-3ff88908113a4ee9aed8e25a586426fb
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09427475B2
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