Potassium Hydroxide → 6-Nitro-7-(3-nitro-4-oxo-4H-pyridin-1-yl-)-1,4-dihydroquinoxaline-2,3-dione

HRID 1488969

반응식

HRID 1488969 반응식
F[C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:13])[C:8](=[O:12])[NH:9]2)=[CH:4][C:3]=1[N+:14]([O-:16])=[O:15].[OH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[N+:24]([O-:26])=[O:25].[OH-].[K+]>CS(C)=O>[N+:14]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[N:21]1[CH:22]=[CH:23][C:18](=[O:17])[C:19]([N+:24]([O-:26])=[O:25])=[CH:20]1)[NH:9][C:8](=[O:12])[C:7](=[O:13])[NH:6]2)([O-:16])=[O:15]

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 99912306-Fluoro-7-nitro-1,4-dihydroquinoxaline-2,3-dioneHCID 178526806HCID 178526806, 화합물

생성물 1

HCID 229035696-Nitro-7-(3-nitro-4-oxo-4H-pyridin-1-yl-)-1,4-dihydroquinoxaline-2,3-dione수율 64.7%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

First, 677 mg of 7-fluoro-6-nitro-1,4-dihydroquinoxaline-2,3-dione, 840 mg of 4-hydroxy-3-nitropyridine, 403 mg of powdered potassium hydroxide were added to 6 ml of dry dimethylsulfoxide. The mixture was allowed to react at 130° C. for 2 hours in a nitrogen atmosphere. The subsequent processes were conducted in the same way as in Example 2. The resultant precipitate was recrystallized with dimethylformaldehyde and water, giving 672 mg of red crystals of 6-nitro-7-(3-nitro-4-oxo-4H-pyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione

후처리

  1. customto react at 130° C. for 2 hours in a nitrogen atmosphere
  2. customThe resultant precipitate was recrystallized with dimethylformaldehyde and water

출처 및 근거

ORD 기록
ord-ff3d3872a8f5421a94d939f717c6b0b0
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05677305

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