Imidazole → Diethyl 3-(tert-Butyldimethylsilyloxy)glutarate

HRID 1489364

반응식

HRID 1489364 반응식
N1C=CN=C1.[C:6]([Si:10](Cl)([CH3:12])[CH3:11])([CH3:9])([CH3:8])[CH3:7].[OH:14][CH:15]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>C(Cl)Cl>[Si:10]([O:14][CH:15]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])([C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:12])[CH3:11]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 96259Diethyl 3-hydroxyglutarate

생성물 1

HCID 13327289Diethyl 3-(tert-Butyldimethylsilyloxy)glutarate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Imidazole and tert-butylchlorodimethylsilane are added to a solution of diethyl 3-hydroxyglutarate in methylene chloride, and the reaction is performed to give diethyl 3-[(tert-butydimethylsilyl)oxy]pentanedioate.

출처 및 근거

ORD 기록
ord-e4ee71123c4e460d8e6cc9a2a88f101a
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05677455

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