Phosphorus oxychloride → HCID 18184384, 화합물

HRID 1489581노트

반응식

HRID 1489581 반응식
O=[C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH2:13][NH:14][CH:3]12.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH:13]=[N:14][C:3]=12

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 69704031HCID 69704031, 화합물

생성물 1

HCID 18184384HCID 18184384, 화합물수율 22%

실험 절차

A suspension of 4-oxo-3H-oxazolo[5,4-g]quinazoline (0.98 g, 5.24 mmol) in POCl3 (30 mL) is heated under reflux with vigorous stirring for 18 h, and then concentrated to dryness. The residue is partitioned between EtOAc and saturated aqueous NaHCO3 and the organic portion is worked up to give 4-chlorooxazolo[5,4-g]quinazoline (0.24g, 22%) as a yellow solid which is used directly.

후처리

  1. temperatureis heated
  2. temperatureunder reflux
  3. concentrationconcentrated to dryness
  4. customThe residue is partitioned between EtOAc and saturated aqueous NaHCO3

출처 및 근거

ORD 기록
ord-203efed6d462496aa462c4202abd6283
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05679683

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