Potassium Permanganate → 3-Benzoyloxy-4-methoxybenzoic acid

HRID 1489697노트

반응식

HRID 1489697 반응식
[Mn]([O-])(=O)(=O)=[O:2].[K+].[C:7]([O:15][C:16]1[CH:21]=[C:20]([CH:22]=[O:23])[CH:19]=[CH:18][C:17]=1[O:24][CH3:25])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[C:7]([O:15][C:16]1[CH:21]=[C:20]([CH:19]=[CH:18][C:17]=1[O:24][CH3:25])[C:22]([OH:2])=[O:23])(=[O:14])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 516875Potassium PermanganateHCID 9581385-Formyl-2-methoxyphenyl benzoate

생성물 1

HCID 211879403-Benzoyloxy-4-methoxybenzoic acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A stirred solution of potassium permanganate (28 g) in acetone (200 mL) is treated with 2-methoxy-5-formylphenyl benzoate (35.2 g; that is prepared as described in Reference Example 8), and the resulting vigorously reacting mixture is cooled in an ice bath. It is then stirred at room temperature for 3 hours. The mixture is then concentrated and the residue is treated with saturated aqueous sodium metabisulfite solution (300 mL). The resulting white solid is filtered off, washed well with water (200 mL), and dried, to give 3-benzoyloxy-4-methoxy-benzoic acid (29.3 g), m.p. 180°-183° C.

후처리

  1. customthat is prepared
  2. temperatureis cooled in an ice bath
  3. concentrationThe mixture is then concentrated
  4. additionthe residue is treated with saturated aqueous sodium metabisulfite solution (300 mL)
  5. filtrationThe resulting white solid is filtered off
  6. washwashed well with water (200 mL)
  7. customdried

출처 및 근거

ORD 기록
ord-3320243d2cad4acb87fde8af7bc960ab
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05679696

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