3-Methoxythioanisole → 2-[3-Methoxy-5-(methylsulfanyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

HRID 1491145

반응식

HRID 1491145 반응식
COc1cccc(SC)c1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[OH2+].C[OH2+].Cc1ccc(C)cc1.Cc1ccnc(-c2cc(C)ccn2)c1.[Ir].[Ir]>COc1cc(SC)cc(B2OC(C)(C)C(C)(C)O2)c1

참가 물질

6

반응물 1

HCID 2811823-Methoxythioanisole

생성물 1

HCID 532172462-[3-Methoxy-5-(methylsulfanyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane수율 69%

시약·촉매·용매 4

HCID 143384,4'-Dimethyl-2,2'-bipyridine시약HCID 2733548Bis(pinacolato)diborane시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 7809P-Xylene용매

반응 조건

온도
55 °C

실험 절차

dtbpy: A mixture of ortho- and meta-borylated products (97 mg, 69% yield, ortho/meta + para = <0.01); meta-Isomer 5i were obtained by further purification by GPC (92 mg, 66% yield), white solid (mp. 73-75 oC)

출처 및 근거

ORD 기록
ord-bc30bcc9f8fa4078b52bc21fad6778ea
출처 데이터셋
Borylation dataset from Roche

연결된 노트

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