N-(2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl)benzamide → N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

HRID 1491211노트

반응식

HRID 1491211 반응식
O=C(Nc1c(F)c(F)c(C(F)(F)F)c(F)c1F)c1ccccc1>CC#N.CC(=O)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.Cc1ccc(S(=O)(=O)O)cc1.O=C(C=Cc1ccc(C(F)(F)F)cc1)C=Cc1ccc(C(F)(F)F)cc1.O=S(=O)(O)OOS(=O)(=O)O.[K].[Na].[Pd]>CC1(C)OB(c2ccccc2C(=O)Nc2c(F)c(F)c(C(F)(F)F)c(F)c2F)OC1(C)C

참가 물질

8

반응물 1

HCID 86708425N-(2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl)benzamide

생성물 1

HCID 101557522N-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide수율 71%

시약·촉매·용매 6

HCID 5922411,5-Bis(4-trifluoromethylphenyl)-penta-1,4-diene-3-one시약HCID 2733548Bis(pinacolato)diborane시약HCID 24195884Sodium p-toluenesulfonate시약HCID 43835029CID 43835029시약HCID 58759193palladium(I) acetate촉매HCID 6342Acetonitrile용매

반응 조건

온도
80 °C

출처 및 근거

ORD 기록
ord-335dd488b93641248c49b4f28e94c5e6
출처 데이터셋
Borylation dataset from Roche

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