1-Phenylisoquinoline → 1-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline

반응식

c1ccc(-c2nccc3ccccc23)cc1>C(=NN(Cc1ccccc1)Cc1ccccc1)c1ccccn1.C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>CC1(C)OB(c2ccccc2-c2nccc3ccccc23)OC1(C)C

참가 물질

반응 조건

온도: 50 °C

실험 절차

Following the general procedure, precipitation from the reaction crude with hexane, trituration and filtration afforded 9n (132 mg, 80 %) as a light brown solid.

출처 및 근거

ORD 기록: ord-9cd5a8a6d6f84ea8b68e2222fc75d190
출처 데이터셋: Borylation dataset from Roche
DOI: 10.1002/anie.201104544

반응 노트

불러오는 중…

참가 물질

반응물 1

HCID 1378821-Phenylisoquinoline

생성물 1

HCID 1407864431-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline수율 78%

시약·촉매·용매 5

HCID 2733548Bis(pinacolato)diborane시약

HCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane시약

HCID 67601456N,N-Dibenzyl-N'-(pyridin-2-ylmethylene)hydrazine시약

HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매

HCID 8028Tetrahydrofuran용매

반응 조건

온도: 50 °C

실험 절차

Following the general procedure, precipitation from the reaction crude with hexane, trituration and filtration afforded 9n (132 mg, 80 %) as a light brown solid.

출처 및 근거

ORD 기록: ord-9cd5a8a6d6f84ea8b68e2222fc75d190
출처 데이터셋: Borylation dataset from Roche
DOI: 10.1002/anie.201104544

반응 노트

불러오는 중…