Ethanol → 2-Methylsulphonyl-3-phenylsulphenylbenzoic acid

HRID 1491579노트

반응식

HRID 1491579 반응식
[CH3:1][S:2]([C:5]1[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])(=[O:4])=[O:3].C(O)C.[OH-].[Na+]>O>[CH3:1][S:2]([C:5]1[C:14]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 18953302Methyl 2-methylsulphonyl-3-phenylsulphenylbenzoate

생성물 1

HCID 189533112-Methylsulphonyl-3-phenylsulphenylbenzoic acid수율 99.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of methyl 2 -methylsulphonyl-3-phenylsulphenylbenzoate (8.3 g), ethanol (50 ml) and 2N sodium hydroxide (25 ml) was heated at reflux for one hour and then added to water. The inorganic phase was washed with ethyl acetate, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. This organic phase was dried over sodium sulphate, filtered and evaporated giving 7.9 g of 2-methylsulphonyl-3-phenylsulphenylbenzoic acid as a white solid, m.p. 185.4°-186.0° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for one hour
  3. washThe inorganic phase was washed with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. dry with materialThis organic phase was dried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-2bea5c5b7e5f4d37890d6d902c04f47e
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371064

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