Pyrrolidine → HCID 18953550, 화합물

HRID 1491639노트

반응식

HRID 1491639 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>O1CCOCC1>[N:11]1([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 27357814-Chloro-3-nitropyridine

생성물 1

HCID 18953550HCID 18953550, 화합물수율 95.4%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-Chloro-3-nitropyridine (2.02 g, 12.7 mmol) was suspended in 15 ml of 1,4-dioxane. The suspension was cooled a little in an ice bath, and then pyrrolidine (2.1 ml, 25.3 mmol ) was added dropwise thereto. The temperature of the suspension was returned to room temperature, and the suspension was stirred for 30 minutes, followed by removal of the solvent by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate) to obtain 2.34 g of a yellow solid (yield: 95.4%).

후처리

  1. temperatureThe suspension was cooled a little in an ice bath
  2. customwas returned to room temperature
  3. customfollowed by removal of the solvent by distillation under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate)

출처 및 근거

ORD 기록
ord-928ee9d366bd43698562826f1125db26
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371086

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