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Acetic Acid → 4-(4-Benzylpiperazinyl)1-phenylcyclohexanecarbonitrile

HRID 1491650
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HRID 1491650 반응식
[C:1]([C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1)#[N:2].[CH2:16]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(O)(=O)C.C([BH3-])#N.[Na+]>C(O)C.O>[CH2:16]([N:23]1[CH2:28][CH2:27][N:26]([CH:6]2[CH2:7][CH2:8][C:3]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)([C:1]#[N:2])[CH2:4][CH2:5]2)[CH2:25][CH2:24]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 759941-BenzylpiperazineHCID 912824-Oxo-1-phenylcyclohexanenitrileHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 540914944-(4-Benzylpiperazinyl)1-phenylcyclohexanecarbonitrile수율 76%

시약·촉매·용매 2

HCID 702Ethanol
용매
HCID 962Water용매

실험 절차

35.0 g of 4-cyano-4-phenylcyclohexanone (0.176 mol), (prepared as disclosed in J. Amer. Chem. Soc. 74, (1972) 773) were dissolved with 31 g of 1-benzylpiperazine (0.176 mol) and 21 g of acetic acid in 200 ml of ethanol and, at room temperature, a solution of 12.5 g of sodium cyanoborohydride (0.19 mol) was slowly added dropwise. The mixture was stirred overnight, and then water was added and the mixture was extracted with dichloromethane. Drying and removal of the solvent by distillation resulted in a residue of 46.6 g (76%) of oil.

후처리

  1. extractionthe mixture was extracted with dichloromethane
  2. customDrying
  3. customremoval of the solvent
  4. distillationby distillation

출처 및 근거

ORD 기록
ord-f94a41dfadc847309d18fd2a95250074
출처 데이터셋
uspto-grants-1994_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05371088

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