Acetic Anhydride → 6-Acetylaminomethyl-2-pyridinecarbonitrile
반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.Cl.[NH2:9][CH2:10][C:11]1[N:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][CH:12]=1>N1C=CC=CC=1>[C:5]([NH:9][CH2:10][C:11]1[N:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][CH:12]=1)(=[O:7])[CH3:6]참가 물질
4
실험 절차
Acetic anhydride (1.29 ml) was added dropwise to a mixture of 6-aminomethyl-2-pyridinecarbonitrile hydrochloride (2.10 g) in pyridine (21 ml). The solution was stirred for four hours at ambient temperature and evaporated in vacuo. The residue was mixed with aqueous potassium carbonate and extracted with ethyl acetate. The extract was dried over magnesium sulfate and evaporated in vacuo to give 6-(acetylaminomethyl)-2-pyridinecarbonitrile (1.72 g).
후처리
- customevaporated in vacuo
- additionThe residue was mixed with aqueous potassium carbonate
- extractionextracted with ethyl acetate
- dry with materialThe extract was dried over magnesium sulfate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-39e3b7a8b3d9471bb130a529af6ba0a5
- 출처 데이터셋
- uspto-grants-1994_12
- 특허 번호
- US05371097
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