6-(Hydroxymethyl)pyridine-2-carboxamide → 6-Formylpicolinamide

HRID 1491821노트

반응식

HRID 1491821 반응식
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)=[O:1]

참가 물질

4

반응물 1

HCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

생성물 1

HCID 189539186-Formylpicolinamide수율 61.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (100 g) and manganese dioxide (500 g) in chloroform (2 l) was heated under reflux for 48 hours. Manganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give 6-formyl-2-pyridinecarboxamide (60.46 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customManganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-0d14b8dd3316448dab3144b334b45322
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371097

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