Acetic Anhydride → HCID 10330249, 화합물

HRID 1491823노트

반응식

HRID 1491823 반응식
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].C(OCC)(=O)C.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1.O>[C:12]([O:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)(=[O:14])[CH3:13]

참가 물질

7

반응물 4

HCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

생성물 1

HCID 10330249HCID 10330249, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (80 g) and acetic anhydride (198.8 ml) in tetrahydrofuran (800 ml) was heated under reflux for 24 hours. The reaction mixture was added to a mixture of ethyl acetate and water and the mixture was adjusted to pH 8 with potassium carbonate. The separated organic layer was washed with brine, dried over magnesium sulfate and evaporated to give 6-acetoxymethyl-2-pyridinecarboxamide (93.34 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. washThe separated organic layer was washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-a41b5d5a4df04f98808c4599264e35b0
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371097

반응 노트

불러오는 중…