Phosphorus oxychloride → 1-Allyl-2-(2-morpholinophenyl)-1,3,3-trimethylguanidine

HRID 1492200

반응식

HRID 1492200 반응식
[CH2:1]([N:4]([CH3:10])[C:5](=O)[N:6]([CH3:8])[CH3:7])[CH:2]=[CH2:3].[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.P(Cl)(Cl)(Cl)=O>C1C=CC=CC=1>[CH2:1]([N:4]([CH3:10])[C:5]([N:6]([CH3:8])[CH3:7])=[N:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 24813Phosphorus oxychlorideHCID 7357562-MorpholinoanilineHCID 189523163-Allyl-1,1,3-trimethylurea

생성물 1

HCID 157464021-Allyl-2-(2-morpholinophenyl)-1,3,3-trimethylguanidine

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

Reaction of 3-allyl-1,1,3-trimethylurea (7.17 g) in benzene (50 ml) with 4-(2-aminophenyl)morpholine (6 g) in benzene (30 ml) in the presence of phosphorus oxychloride (4.71 ml) for 45 hours at 70° C. gave 1-allyl-2-(2-morpholinophenyl)-1,3,3-trimethylguanidine (bp. 148°-150° C. at 0.2 mm Hg).

출처 및 근거

ORD 기록
ord-0607a0d79f4745e199209c9667db503e
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05373008

연결된 노트

불러오는 중…