Potassium Hydroxide → N-(2-morpholinophenyl)cyanamide

HRID 1492277노트

반응식

HRID 1492277 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:13][C:14]([NH2:16])=S)[CH2:3][CH2:2]1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:13][C:14]#[N:16])[CH2:5][CH2:6]1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 27411931-(2-Morpholinophenyl)thiourea

생성물 1

HCID 15746517N-(2-morpholinophenyl)cyanamide

시약·촉매·용매 1

HCID 962Water용매3회

반응 조건

온도
90 °C

실험 절차

1-(2-morpholinophenyl)thiourea (10.6 g) was suspended in boiling water (80 ml) and a solution of potassium hydroxide (25.2 g) in hot water (70 ml) was added. The mixture was heated to 90° C. and aliquot portions of a hot solution of lead acetate trihydrate (17.5 g) in water (80 ml) added and the mixture heated under reflux for 10 minutes and cooled to ambient temperature. The mixture was filtered and the filtrate acidified with acetic acid to pH 6. The solid which formed was separated by filtration, washed with water and recrystallised from ethylacetate to give N-(2-morpholinophenyl)cyanamide (m.p. 175°-176° C.).

후처리

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 10 minutes
  3. temperaturecooled to ambient temperature
  4. filtrationThe mixture was filtered
  5. customThe solid which formed
  6. customwas separated by filtration
  7. washwashed with water
  8. customrecrystallised from ethylacetate

출처 및 근거

ORD 기록
ord-d957ba0cc2704dbcaa2affdfdf0bde80
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05373008

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